What is the Hip Joint?

The hip joint is a ball and socket synovial joint, formed by an articulation between the pelvic acetabulum and the head of the femur. It forms a connection from the lower limb to the pelvic girdle, and thus is designed for stability and weight-bearing

Importance of Hip Joint

  • The hip joint is one of the most important joints in the human body.
  • It allows us to walk, run, and jump. It bears our body's weight and the force of the strong muscles of the hip and leg.
  • The femur, or thighbone, is the longest and strongest bone in the body.

What is Avascular Necrosis (AVN) / Osteonecrosis (ON)?

AVN/ON is the localized death of bone tissue as a result of injury (trauma), drug side effects, or a pre-existing disease

  • Bone is a living tissue that requires continuous blood supply
  • Just like in heart attack, where lack of blood supply leads to death of heart muscle, ON arises due to lack of blood supply to the bone
  • ON commonly affects the upper part of the thigh bone or femoral head.
  • With no blood supply, bone tissue in the femoral head starts to deteriorate.
  • Gradual bone death leads to the break-down of the femoral head.

Causes of AVN/ ON

  • High-dose corticosteroid use
  • Alcohol abuse
  • Smoking
  • Trauma /accidents
  • Idiopathic

Risk factors for Osteonecrosis

  • Post Solid organ transplantation
  • Asthma
  • Cancer
  • Renal Failure
  • Inflammatory Bowel Disease
  • Systemic lupus erythematosus


  • Young population (20-40 age group)
  • US - 160,000 affected with ON
  • EU - 230,000 affected with ON
  • Without definitive treatment, 80% of all ON cases will progress within 3 years and inevitably undergo hip replacement
  • In more than 60% of the patients, both joints will be affected (bilateral)
  • On the basis of 2000-to-2014 data, primary total hip arthroplasty (THA) is projected to grow 71%, to 635,000 procedures, by 2030 in the US

Progression of Disease

  • Dead bone tissue does not function normally and leads to a break-down of the affected joint.
  • After the bone collapse, there is the destruction of the cartilage joint adjacent to the affected bone that leads to irreversible arthritic changes leading to severe pain.

The Arco Classification Of Osteonecrosis

By the ARCO-Committee on Terminology and Staging


Staging is a method of following the development of the disease and a way to start to treat the patient. Staging has to include the onset of the disease, Stage "0", and extend till the final end, the complete joint destruction.

How are we treating Avascular Necrosis Today?

Unmet Clinical need

Biologic repair is now possible through Cell therapies such as Autologous Osteoblast Implantation

What is Autologous Adult Live Cultured Osteoblasts?

  • Targeted and personalized bone cell therapy
  • Uses patients bone marrow as a source for bone making cells or osteoblasts
  • Formation of new bone preserves the structural-functional integrity of the joint
  • The femoral head is saved from a breakdown or joint collapse
  • Eliminates the need for Total Hip Arthroplasty
  • The patient is pain-free and returns to active normal life
  • Monetary burden from prospective surgeries lifted & Quality of life restored

Goal of Treatment

  • Initiate new blood supply
  • Remove dead bone
  • Form new bone
  • Stop the progression of the disease
  • In best-case scenario complete reversal of the disease

Need for Globally approved treatments for Joint Preservation

  • It is estimated that 70–80 % of osteonecrosis patients experience femoral head collapse, for which total hip arthroplasty is considered the most effective treatment, even in young patients
  • There is a crucial need for developing a minimally invasive regenerative therapy as a preventive surgery for femoral head collapse.
  • Core decompression, the most popular minimally invasive surgery for osteonecrosis of the femoral head, has been used for a long time; however, it has been insufficient to prevent femoral head collapse.

Case Reports

Our Process

Step 1

Bone Marrow Aspiration /Biopsy

  • A simple day-care procedure involving the extraction (biopsy) of a small quantity (4 ml) of your bone marrow will be performed. The procedure usually lasts for 10-15 minutes. The patient is usually given local anesthesia.
  • The bone marrow biopsy is aseptically transported under cold chain (low temperature) to a centralized GMP certified cell culture laboratory. Bone forming cells called osteoblasts are cultures within 14 -21 days.

Step 2

Osteoblast Implantation

Implantation Procedure:

  • The cultured cells (48 millions) are simply implanted onto the damaged area of the hip.
  • The implantation procedure usually lasts for about 30 – 45 minutes where, the patient is given spinal or general anesthesia. Patient returns home in about 2 days of time.
  • Through constantly guided physiotherapy including the muscle strengthening and load bearing capacity exercises, the new bone tissue formed becomes mechanically very robust allowing all activities as early as 6 months.

Billing and Insurance

  • Government purchases can be made through direct purchase option on https://bit.ly/2LuYYtR
  • All Regrow bills include transport and delivery kit charges.
  • Regrow invoice is submitted at the time of biopsy to private institutions.
  • Regrow products are covered by all private and Govt.insurance schemes.

To place the order or to know more about the product, please call :

Dr. Charul Bhanji
Technical Director

Mr. Amos Chopade
Medical Officer

Medical Education

Please refer to our academic library for peer reviewed International Publications on ACI

Autologous Osteoblast Implantation - A Boon To Boneaugmentation (A Case Report)
Bilateral Maxillary Sinus Floor Augmentation With Tissue‑Engineered Autologous Osteoblasts and Demineralized Freeze‑dried Bone.
Ossgrow Whitepaper - A prospective Monocentric report on the use of autologous adult live cultured Osteoblast (Ossgrow) for the treatment of patients with Avascular Necrosis of the hip.
Autologous Human Osteoblasts for Maxillofacial Bone Tissue Engineering - Ex Vivo Good Manufacturing Practice (GMP) - Level Expansion and Clinical Evaluation
Autologous Osteoblast - cell Therapy in Orthodontics and Implantology - A Single-center Experience of Nine Patients
Fibrous Dysplasia - A Case Report of Novel Treatment Approach
Use of Autologous Mesenchymal Stem Cells in Treatment of Avascular Necrosis of the Hip - Technical Report and Results of a Case Study
Retrospective Study on Implantation of Autologous- Cultured Osteoblasts for the Treatment of Patients with Avascular Necrosis of the Femoral Head
Hip Preservation With Autologous Osteoblast Cell-Based Treatment in Osteonecrosis of the Femoral Head
Compendium on Non Union Fractures
Treatment of Femoral Neck Non-Union using Bone Cell Therapy : A case report
A Case Report on Steroid-Induced Avascular Necrosis Treated with Autologous Adult Live-Cultured Osteoblasts (AALCO) in COVID-19 Patient
Fibular Hemimelia Treated by Autologous Osteoblasts
Biological Therapy for Avascular Necrosis of Femoral Head – A Case
Short-term Follow-up of Autologous Adult Live-Cultured Osteoblasts

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