What is Bone Structure and Avascular Necrosis?

The human skeleton is the internal framework of the human body and provides physical support for the organ systems.Bone is a rigid tissue that carries out a myriad of functions in our body. Apart from supportive functions, blood cell production, storage of important minerals andendocrineregulation takes place in the bone.

Although one may think of the bone as a completely hard material, the interior is composed of spongy and dynamic living tissue including bone marrow where blood cells are made.

Several cellular processes take place in the bone and tissue is continually being built, broken down and rebuilt. The cells responsible for making new bone are called as osteoblasts. Bone is broken down by osteoclasts. As osteoblasts form new bone tissue, many become embedded within the bone matrix and differentiate into mature bone called as osteocytes.Osteocytes form a complex network in the bone. The blood vessels within the bone facilitate the exchange of oxygen and nutrients between osteocytes and keeps the bone nourished and healthy. The cellular processes that occur within the bone allow it to simultaneously serve as a calcium reservoir while providing structural support for the vital organs and for locomotion.

The National Institutes of Health lists over 50 diseases that are associated with the bone. Bone disease types include bone cysts, developmental, endocrine, infectious, metabolic, spinal and ischemic. Ischemia is reduction in blood supply leading to shortage of oxygen and nutrients that is necessary for cellular metabolism. It is usually caused due to blocked arteries that supply blood. This is a major cause of disease in failure of organ functions such as ischemic cardiomyopathy, ischemic stroke, ischemic colitis, cerebral ischemia to name a few.

When bone tissue becomes ischemic, it causes ‘bone attack’ that leads to changes in cellular processes which affect bone functions. This disease is called Osteonecrosis (also called as Avascular necrosis). Avascular means no blood supply and necrosis means death. Lack of blood supply to the bone and subsequentdeficiency in oxygen and key nutrients leads to death of osteocytes. Gradualbone death causes microfractures which eventually affects the biomechanical properties of the joint and leads to collapse. Avascular Necrosis mostly affects the hip joint.

Avascular Necrosis (AVN), if not treated in time collapses the affected joint, and leads to the Replacement Surgery. Patients suffering from Avascular Necrosis (AVN) can stop the progression of AVN with the help of OSSGROW® (Bone Cell Therapy). OSSGROW® is World’s First and the only cell therapy that cures Avascular Necrosis (AVN) and stops the disease progression.

Click Here To know more about OSSGROW® - Bone Cell Therapy or Click Here To View The Experience of Avascular Necrosis Patients, Treated by OSSGROW®.

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